English
norskBlar i forfatter "Schots, Pauke C."
Viser treff 1-6 av 6
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Calanus oil and its constituents as a therapeutic approach to target obesity-induced metabolic distortions
(Doctoral thesis; Doktorgradsavhandling, 2023-11-24)Obesity is one of the leading causes for the development of metabolic disorders, such as insulin resistance and type 2 diabetes. Omega-3 fatty acids, found in seafood and marine oils, are shown to reduce obesity, lower blood lipid levels, change the composition of the gut microbiota and reduce the risk for cardiovascular diseases. The increased demand for seafood and marine oils has put pressure on ... -
Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)Objective: To compare administration of the glucagon-like peptide-1 (GLP-1) analogue, exenatide, versus dietary supplementation with the omega-3 fatty acid-rich Calanus oil on obesity-induced alterations in mitochondrial respiration.<p> <p>Methods: Six-week-old female C57BL/6JOlaHSD mice were given high fat diet (HFD, 45% energy from fat) for 12 weeks to induce obesity. Thereafter, they were ... -
Obesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oil
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-09)Dietary supplementation with calanus oil, a novel wax ester–rich marine oil, has been shown to reduce adiposity in high-fat diet (HFD)–induced obese mice. Current evidence suggests that obesity and its comorbidities are intrinsically linked with unfavorable changes in the intestinal microbiome. Thus, in line with its antiobesity effect, we hypothesized that dietary supplementation with calanus oil ... -
Possible Health Effects of a Wax Ester Rich Marine Oil
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)The consumption of seafood and the use of fish oil for the production of nutraceuticals and fish feed have increased over the past decades due the high content of long-chain polyunsaturated omega-3 fatty acids. This increase has put pressure on the sustainability of fisheries. One way to overcome the limited supply of fish oil is to harvest lower in the marine food web. <i>Calanus finmarchicus</i>, ... -
Seasonal changes in background levels of deuterium and oxygen- 18 prove water drinking by harp seals, which affects the use of the doubly labelled water method
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-29)The aim of this study was to monitor seasonal changes in stable isotopes of pool freshwater and harp seal (Phoca groenlandica) body water, and to study whether these potential seasonal changes might bias results obtained using the doubly labelled water (DLW) method when measuring energy expenditure in animals with access to freshwater. Seasonal changes in the background levels of deuterium and ... -
A simple method to isolate fatty acids and fatty alcohols from wax esters in a wax-ester rich marine oil
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-12)Calanus finmarchicus is one of the most important zooplankton species in the North Atlantic. The zooplankton is currently being harvested and industrially processed to a marine oil product for human consumption as a marine nutraceutical containing long-chain omega-3 polyunsaturated fatty acids. This oil is very rich in wax esters, a lipid class where fatty acids are esterified to long chain fatty ...
